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Background: Over the last few years only one large random-ized phase III study has tried to prospectively assess the safety of cetuximab and panitumumab in a head-to-head comparison. Despite the similar overall toxicity profile, ce-tuximab and Panitumumab vs. Cetuximab Although they both target the EGFR, panitumumab ( IgG2 ) and cetuximab ( IgG1 ) differ in their isotype and they might differ in their mechanism of action. Monoclonal antibodies of the IgG1 isotype may activate the complement pathway and mediate antibody-dependent cellular cytotoxicity (ADCC).  ASPECCT study Conclusions . First phase 3 study evaluating the efficacy and safety of panitumumab vs. cetuximab in 3rd-line WT KRAS exon 2 mCRC ASPECCT met its primary endpoint of non-inferiority for OS Panitumumab retained 106% (95% CI, 82–129) of the OS benefit of cetuximab over BSC in patients with WT KRAS exon 2 mCRC Observed safety Background Treatment with cetuximab, panitumumab, has been compared with supportive care in a phase 3 trial.
Clinical Trial Registration : ASPECCT trial registered with ClinicalTrials.gov (NCT01001377) and WJOG … Background: Over the last few years only one large randomized phase III study has tried to prospectively assess the safety of cetuximab and panitumumab in a head-to-head comparison. Despite the similar overall toxicity profile, cetuximab and panitumumab retain peculiar safety characteristics that deserve to be deeply investigated. Background In the absence of comparative studies of cetuximab vs. panitumumab in metastatic colorectal cancer (MCCR), we suggested performing an indirect comparison of the two drugs for this indication.
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La sopravvivenza mediana era di 10.4 mesi per i pazienti randomizzati a panitumumab (95%CI 9.4-11.6) vs 10 mesi (95% CI 9.3-11.0) per quelli che ricevevano cetuximab (HR 0.97, 95%CI 0.84-1.11). ASPECCT study Conclusions . First phase 3 study evaluating the efficacy and safety of panitumumab vs.
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p= 0,016 3).
In this study, we performed exploratory analyses of updated survival data using the KRAS exon 2 and RAS/BRAF statuses. Panitumumab vs.
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The ORR was 22.0% with panitumumab and 19.8% with. cetuximab.
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Panitumumab Plus Irinotecan vs Cetuximab Plus Irinotecan in KRAS Wild-Type mCRC Refractory to Fluoropyrimidine, Irinotecan, and Oxaliplatin European Journal of Cancer . Background Treatment with cetuximab, a monoclonal antibody directed against the epidermal growth factor receptor, improves overall and progression-free survival and preserves the quality of life in
The ASPECCT study met its primary endpoint of noninferiority for improving overall survival in patients taking panitumumab vs cetuximab (Erbitux, Lilly/Bristol-Myers Squibb) as a single agent for
In termini di OS, il panitumumab si e' dimostrato non inferiore al cetuximab (Z score -3.19< p=0.0007). La sopravvivenza mediana era di 10.4 mesi per i pazienti randomizzati a panitumumab (95%CI 9.4-11.6) vs 10 mesi (95% CI 9.3-11.0) per quelli che ricevevano cetuximab (HR 0.97, 95%CI 0.84-1.11). ASPECCT study Conclusions .
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To evaluate the significance of drug substitution on the cost of care we assessed the economic value of panitumumab vs. cetuximab in chemo-refractory metastatic CRC (mCRC) with wild-type KRAS from a US societal Cetuximab was approved by the FDA in March 2006 for use in combination with radiation therapy for treating squamous cell carcinoma of the head and neck or as a single agent in patients who have had prior platinum-based therapy.
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The panitumumab or cetuximab monotherapy (ASPECCT) was the first head-to-head, randomised, phase-III study of panitumumab versus cetuximab for the treatment of chemotherapy-refractory wild-type KRAS exon 2 metastatic colorectal cancer (February 2010 to July 2012). The primary analysis demonstrated that panitumumab was non-inferior to cetuximab, and that both agents provided a similar overall By William B. Ershler, MD. Synopsis: A previously reported, industry-sponsored phase 3 trial (Study 20050181 1) showed improvements in progression-free survival, objective response, and a non-significant trend toward increased overall survival with panitumumab-FOLFIRI vs FOLFIRI alone for second-line wild-type KRAS metastatic colorectal cancer.The current report describes long-term … Panitumumab vs. Cetuximab. Although they both target the EGFR, panitumumab and cetuximab differ in their isotype and they might differ in their mechanism of action.
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For the primary analysis of overall survival, panitumumab was non-inferior to cetuximab (Z score -3.19; p=0.0007). Median overall survival was 10.4 months (95% CI 9.4-11.6) with panitumumab and 10.0 months (9.3-11.0) with cetuximab (HR 0.97; 95% CI 0.84-1.11). Our findings show that panitumumab is non-inferior to cetuximab and that these agents provide similar overall survival benefit in this population of patients.
We read with interest Timothy Price and colleagues' report of the results of ASPECCT,1 a randomised phase 3 trial that compared cetuximab and panitumumab in patients with chemotherapy-refractory KRAS exon 2 wild-type colorectal cancer.